OTU deubiquitinase, ubiquitin aldehyde binding 2
Symbol
OTUB2
(may also be known as: None)
Organism
Human
Description
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| otub-1 | Caenorhabditis elegans | |
| Otub2 | Mus musculus | |
| Otub2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006508 | proteolysis | biological_process | |
| GO:0006520 | cellular amino acid metabolic process | biological_process | |
| GO:0016579 | protein deubiquitination | biological_process | |
| GO:0070536 | protein K63-linked deubiquitination | biological_process | |
| GO:0071108 | protein K48-linked deubiquitination | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0004843 | ubiquitin-specific protease activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0008234 | cysteine-type peptidase activity | molecular_function | |
| GO:0008242 | omega peptidase activity | molecular_function | |