vascular cell adhesion molecule 1

Symbol

VCAM1 (may also be known as: None)

Organism

Human

Description

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Orthologs

SymbolSpecies
vcam1 Danio rerio
Vcam1 Mus musculus
Vcam1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2840 Gene expression of VCAM1 increases with age Molecular adipose tissue Human VCAM1 —

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0002526 acute inflammatory response biological_process
GO:0002544 chronic inflammatory response biological_process
GO:0007155 cell adhesion biological_process
GO:0007157 heterophilic cell-cell adhesion biological_process
GO:0007159 leukocyte cell-cell adhesion biological_process
GO:0007507 heart development biological_process
GO:0007568 aging biological_process
GO:0007584 response to nutrient biological_process
GO:0010212 response to ionizing radiation biological_process
GO:0016337 cell-cell adhesion biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0022614 membrane to membrane docking biological_process
GO:0030183 B cell differentiation biological_process
GO:0042102 positive regulation of T cell proliferation biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0050776 regulation of immune response biological_process
GO:0050901 leukocyte tethering or rolling biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0060669 embryonic placenta morphogenesis biological_process
GO:0060710 chorio-allantoic fusion biological_process
GO:0002102 podosome cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005902 microvillus cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030175 filopodium cellular_component
GO:0042383 sarcolemma cellular_component
GO:0045177 apical part of cell cellular_component
GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular_component
GO:0005178 integrin binding molecular_function
GO:0050839 cell adhesion molecule binding molecular_function