nuclear receptor subfamily 1, group H, member 2

Symbol

NR1H2 (may also be known as: None)

Organism

Human

Description

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Orthologs

SymbolSpecies
Nr1h2 Mus musculus
Nr1h2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2081 nuclear receptor subfamily 1, group H, member 2 increases with age Molecular ovary Human NR1H2 77.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0010467 gene expression biological_process
GO:0010745 negative regulation of macrophage derived foam cell differentiation biological_process
GO:0010867 positive regulation of triglyceride biosynthetic process biological_process
GO:0010875 positive regulation of cholesterol efflux biological_process
GO:0010884 positive regulation of lipid storage biological_process
GO:0010887 negative regulation of cholesterol storage biological_process
GO:0030522 intracellular receptor mediated signaling pathway biological_process
GO:0032270 positive regulation of cellular protein metabolic process biological_process
GO:0032369 negative regulation of lipid transport biological_process
GO:0032376 positive regulation of cholesterol transport biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0045723 positive regulation of fatty acid biosynthetic process biological_process
GO:0045861 negative regulation of proteolysis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048384 retinoic acid receptor signaling pathway biological_process
GO:0048550 negative regulation of pinocytosis biological_process
GO:0051006 positive regulation of lipoprotein lipase activity biological_process
GO:0055088 lipid homeostasis biological_process
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway biological_process
GO:0090108 positive regulation of high-density lipoprotein particle assembly biological_process
GO:0090187 positive regulation of pancreatic juice secretion biological_process
GO:0090340 positive regulation of secretion of lysosomal enzymes biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003707 steroid hormone receptor activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046965 retinoid X receptor binding molecular_function