TYRO protein tyrosine kinase binding protein

Symbol

TYROBP (may also be known as: None)

Organism

Human

Description

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Orthologs

SymbolSpecies
tyrobp Danio rerio
Tyrobp Mus musculus
Tyrobp Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3451 Gene expression of TYROBP decreases with age Molecular skin Human TYROBP —

GO Terms

GO IDGO TermGO Category
GO:0006968 cellular defense response biological_process
GO:0007165 signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0050776 regulation of immune response biological_process
GO:0005622 intracellular cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005057 receptor signaling protein activity molecular_function
GO:0005515 protein binding molecular_function
GO:0042802 identical protein binding molecular_function