Tu translation elongation factor, mitochondrial
Symbol
TUFM
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| tufm-1 | Caenorhabditis elegans | |
| EfTuM | Drosophila melanogaster | |
| tufm | Danio rerio | |
| Gm9755 | Mus musculus | |
| Tufm | Rattus norvegicus | |
| TUF1 | Saccharomyces cerevisiae | |
| tuf1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006414 | translational elongation | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0042645 | mitochondrial nucleoid | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003746 | translation elongation factor activity | molecular_function | |
| GO:0003924 | GTPase activity | molecular_function | |
| GO:0005525 | GTP binding | molecular_function | |