trichorhinophalangeal syndrome I

Symbol

TRPS1 (may also be known as: None)

Organism

Human

Description

This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
Trps1	Mus musculus
Trps1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2624	Hypomethylation of TRPS1 is positively correlated with age	Molecular	blood	Human	TRPS1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0001501	skeletal system development	biological_process
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0006366	transcription from RNA polymerase II promoter	biological_process
GO:0006607	NLS-bearing substrate import into nucleus	biological_process
GO:0032330	regulation of chondrocyte differentiation	biological_process
GO:0045892	negative regulation of transcription, DNA-dependent	biological_process
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0043565	sequence-specific DNA binding	molecular_function
GO:0046872	metal ion binding	molecular_function
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