complement component 1, q subcomponent, B chain
Symbol
C1QB
(may also be known as: None)
Organism
Human
Description
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| c1qc | Danio rerio | |
| C1qb | Mus musculus | |
| C1qb | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2166 | complement component 1, q subcomponent, B chain increases with age | Molecular | temporal lobe | Human | C1QB | 186.7% Increase Gene Expression Level | |
| DAA2170 | complement component 1, q subcomponent, B chain increases with age | Molecular | hippocampus | Human | C1QB | 391.4% Increase Gene Expression Level | |
| DAA2182 | complement component 1, q subcomponent, B chain increases with age | Molecular | parietal lobe | Human | C1QB | 288.1% Increase Gene Expression Level | |
| DAA2195 | complement component 1, q subcomponent, B chain increases with age | Molecular | frontal lobe | Human | C1QB | 166.8% Increase Gene Expression Level | |
| DAA3017 | Gene expression of C1QB decreases with age | Molecular | skin | Human | C1QB | — |
Changes associated with the orthologs of this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA1398 | complement component 1, q subcomponent, beta polypeptide | Molecular | hippocampus | Mouse | C1qb | 3.0% Increase Gene Expression Level | |
| DAA1491 | complement component 1, q subcomponent, beta polypeptide | Molecular | kidney | Mouse | C1qb | 9.0% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006956 | complement activation | biological_process | |
| GO:0006958 | complement activation, classical pathway | biological_process | |
| GO:0007420 | brain development | biological_process | |
| GO:0007568 | aging | biological_process | |
| GO:0010033 | response to organic substance | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0051384 | response to glucocorticoid stimulus | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005581 | collagen | cellular_component | |
| GO:0005602 | complement component C1 complex | cellular_component | |
| GO:0042803 | protein homodimerization activity | molecular_function | |