TIA1 cytotoxic granule-associated RNA binding protein-like 1

Symbol

TIAL1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
tiar-2	Caenorhabditis elegans
tial1	Danio rerio
Tial1	Mus musculus
Tial1	Rattus norvegicus
NGR1	Saccharomyces cerevisiae
csx1	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2641	Hypomethylation of TIAL1 is positively correlated with age	Molecular	blood	Human	TIAL1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological_process
GO:0006915	apoptotic process	biological_process
GO:0006917	induction of apoptosis	biological_process
GO:0006952	defense response	biological_process
GO:0007281	germ cell development	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0017145	stem cell division	biological_process
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005764	lysosome	cellular_component
GO:0010494	cytoplasmic stress granule	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0003676	nucleic acid binding	molecular_function
GO:0003723	RNA binding	molecular_function
GO:0017091	AU-rich element binding	molecular_function
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