TIA1 cytotoxic granule-associated RNA binding protein-like 1
Symbol
TIAL1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| tiar-2 | Caenorhabditis elegans | |
| tial1 | Danio rerio | |
| Tial1 | Mus musculus | |
| Tial1 | Rattus norvegicus | |
| NGR1 | Saccharomyces cerevisiae | |
| csx1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006917 | induction of apoptosis | biological_process | |
| GO:0006952 | defense response | biological_process | |
| GO:0007281 | germ cell development | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0017145 | stem cell division | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0010494 | cytoplasmic stress granule | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0017091 | AU-rich element binding | molecular_function | |