thrombospondin 2
Symbol
THBS2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| thbs2b | Danio rerio | |
| Thbs2 | Mus musculus | |
| Thbs2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007155 | cell adhesion | biological_process | |
| GO:0016525 | negative regulation of angiogenesis | biological_process | |
| GO:0051965 | positive regulation of synapse assembly | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0031012 | extracellular matrix | cellular_component | |
| GO:0005198 | structural molecule activity | molecular_function | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008201 | heparin binding | molecular_function | |