transforming growth factor, beta-induced, 68kDa
Symbol
TGFBI
(may also be known as: None)
Organism
Human
Description
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| tgfbi | Danio rerio | |
| Tgfbi | Mus musculus | |
| Tgfbi | Rattus norvegicus | |
| SPAC22H12.05c | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001525 | angiogenesis | biological_process | |
| GO:0002062 | chondrocyte differentiation | biological_process | |
| GO:0007155 | cell adhesion | biological_process | |
| GO:0007162 | negative regulation of cell adhesion | biological_process | |
| GO:0007601 | visual perception | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0030198 | extracellular matrix organization | biological_process | |
| GO:0050896 | response to stimulus | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0031012 | extracellular matrix | cellular_component | |
| GO:0005178 | integrin binding | molecular_function | |
| GO:0050840 | extracellular matrix binding | molecular_function | |