trefoil factor 3 (intestinal)

Symbol

TFF3 (may also be known as: None)

Organism

Human

Description

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Tff3 Mus musculus
Tff3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3430 Gene expression of TFF3 decreases with age Molecular skin Human TFF3 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1529 trefoil factor 3, intestinal Molecular liver Mouse Tff3 97.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006952 defense response biological_process
GO:0007586 digestion biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0030141 secretory granule cellular_component
GO:0032579 apical lamina of hyaline layer cellular_component
GO:0003674 molecular_function molecular_function