transcobalamin II
Symbol
TCN2
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| tcn2l | Danio rerio | |
| Tcn2 | Mus musculus | |
| Tcn2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006811 | ion transport | biological_process | |
| GO:0006824 | cobalt ion transport | biological_process | |
| GO:0009235 | cobalamin metabolic process | biological_process | |
| GO:0015889 | cobalamin transport | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0031419 | cobalamin binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |