mitogen-activated protein kinase kinase kinase 7

Symbol

MAP3K7 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CELE_Y105C5A.24 Caenorhabditis elegans
Tak1 Drosophila melanogaster
map3k7 Danio rerio
Map3k7 Mus musculus
Map3k7 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3420 Gene expression of MAP3K7 increases with age Molecular skin Human MAP3K7 —

GO Terms

GO IDGO TermGO Category
GO:0000186 activation of MAPKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0001525 angiogenesis biological_process
GO:0001841 neural tube formation biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002726 positive regulation of T cell cytokine production biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006950 response to stress biological_process
GO:0007165 signal transduction biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007249 I-kappaB kinase/NF-kappaB cascade biological_process
GO:0007250 activation of NF-kappaB-inducing kinase activity biological_process
GO:0007252 I-kappaB phosphorylation biological_process
GO:0007254 JNK cascade biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0032743 positive regulation of interleukin-2 production biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043507 positive regulation of JUN kinase activity biological_process
GO:0043966 histone H3 acetylation biological_process
GO:0045087 innate immune response biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0050870 positive regulation of T cell activation biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0008385 IkappaB kinase complex cellular_component
GO:0010008 endosome membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0000287 magnesium ion binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004709 MAP kinase kinase kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function