ELOVL fatty acid elongase 4

Symbol

ELOVL4 (may also be known as: None)

Organism

Human

Description

This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Elo68alpha Drosophila melanogaster
elovl4a Danio rerio
Elovl4 Mus musculus
Elovl4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3415 Gene expression of ELOVL4 decreases with age Molecular skin Human ELOVL4 —

GO Terms

GO IDGO TermGO Category
GO:0006633 fatty acid biosynthetic process biological_process
GO:0009584 detection of visible light biological_process
GO:0019367 fatty acid elongation, saturated fatty acid biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process biological_process
GO:0042761 very long-chain fatty acid biosynthetic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0005515 protein binding molecular_function
GO:0008020 G-protein coupled photoreceptor activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function