sterol regulatory element binding transcription factor 1

Symbol

SREBF1 (may also be known as: None)

Organism

Human

Description

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
srebf1 Danio rerio
Srebf1 Mus musculus
Srebf1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3411 Gene expression of SREBF1 decreases with age Molecular skin Human SREBF1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0003062 regulation of heart rate by chemical signal biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0006629 lipid metabolic process biological_process
GO:0007568 aging biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0009267 cellular response to starvation biological_process
GO:0009749 response to glucose stimulus biological_process
GO:0010867 positive regulation of triglyceride biosynthetic process biological_process
GO:0019217 regulation of fatty acid metabolic process biological_process
GO:0030324 lung development biological_process
GO:0031065 positive regulation of histone deacetylation biological_process
GO:0032094 response to food biological_process
GO:0032526 response to retinoic acid biological_process
GO:0032570 response to progesterone stimulus biological_process
GO:0033762 response to glucagon stimulus biological_process
GO:0035104 positive regulation of transcription via sterol regulatory element binding biological_process
GO:0042493 response to drug biological_process
GO:0045542 positive regulation of cholesterol biosynthetic process biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046676 negative regulation of insulin secretion biological_process
GO:0051591 response to cAMP biological_process
GO:0070542 response to fatty acid biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0012507 ER to Golgi transport vesicle membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0043234 protein complex cellular_component
GO:0044444 cytoplasmic part cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0032810 sterol response element binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function