sterol O-acyltransferase 1

Symbol

SOAT1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Orthologs

SymbolSpecies
soat1 Danio rerio
Soat1 Mus musculus
Soat1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3404 Gene expression of SOAT1 decreases with age Molecular skin Human SOAT1 —

GO Terms

GO IDGO TermGO Category
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0010742 macrophage derived foam cell differentiation biological_process
GO:0010878 cholesterol storage biological_process
GO:0033344 cholesterol efflux biological_process
GO:0034379 very-low-density lipoprotein particle assembly biological_process
GO:0034435 cholesterol esterification biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000062 fatty-acyl-CoA binding molecular_function
GO:0004772 sterol O-acyltransferase activity molecular_function
GO:0008374 O-acyltransferase activity molecular_function
GO:0015485 cholesterol binding molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function
GO:0034736 cholesterol O-acyltransferase activity molecular_function