cytochrome P450, family 4, subfamily F, polypeptide 12

Symbol

CYP4F12 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4100 Gene expression of CYP4F12 increases with age Molecular skin Human CYP4F12 —

GO Terms

GO IDGO TermGO Category
GO:0000038 very long chain fatty acid metabolic process biological_process
GO:0001676 long-chain fatty acid metabolic process biological_process
GO:0003091 renal water homeostasis biological_process
GO:0003095 pressure natriuresis biological_process
GO:0006805 xenobiotic metabolic process biological_process
GO:0017144 drug metabolic process biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0019373 epoxygenase P450 pathway biological_process
GO:0030195 negative regulation of blood coagulation biological_process
GO:0042360 vitamin E metabolic process biological_process
GO:0042371 vitamin K biosynthetic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055078 sodium ion homeostasis biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0004497 monooxygenase activity molecular_function
GO:0008392 arachidonic acid epoxygenase activity molecular_function
GO:0009055 electron carrier activity molecular_function
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function
GO:0018685 alkane 1-monooxygenase activity molecular_function
GO:0020037 heme binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity molecular_function
GO:0050051 leukotriene-B4 20-monooxygenase activity molecular_function
GO:0070330 aromatase activity molecular_function