BMX non-receptor tyrosine kinase
Symbol
BMX
(may also be known as: None)
Organism
Human
Description
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| Bmx | Mus musculus | |
| Bmx | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2785 | Gene expression of BMX increases with age | Molecular | adipose tissue | Human | BMX | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006921 | cellular component disassembly involved in apoptosis | biological_process | |
| GO:0006950 | response to stress | biological_process | |
| GO:0007155 | cell adhesion | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007498 | mesoderm development | biological_process | |
| GO:0035556 | intracellular signal transduction | biological_process | |
| GO:0046777 | protein autophosphorylation | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0032587 | ruffle membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | molecular_function | |
| GO:0004871 | signal transducer activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |