solute carrier family 6 (neurotransmitter transporter), member 8

Symbol

SLC6A8 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Orthologs

SymbolSpecies
slc6a8 Danio rerio
Slc6a8 Mus musculus
Slc6a8 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3397 Gene expression of SLC6A8 increases with age Molecular skin Human SLC6A8 —

GO Terms

GO IDGO TermGO Category
GO:0006600 creatine metabolic process biological_process
GO:0006810 transport biological_process
GO:0006811 ion transport biological_process
GO:0006814 sodium ion transport biological_process
GO:0006836 neurotransmitter transport biological_process
GO:0006936 muscle contraction biological_process
GO:0015881 creatine transport biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0005308 creatine transporter activity molecular_function
GO:0005309 creatine:sodium symporter activity molecular_function
GO:0005328 neurotransmitter:sodium symporter activity molecular_function
GO:0015220 choline transmembrane transporter activity molecular_function
GO:0015293 symporter activity molecular_function