UPF3 regulator of nonsense transcripts homolog B (yeast)
Symbol
Organism
Description
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| upf3b | Danio rerio | |
| Upf3b | Mus musculus | |
| Upf3b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | biological_process | |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0006369 | termination of RNA polymerase II transcription | biological_process | |
| GO:0006406 | mRNA export from nucleus | biological_process | |
| GO:0006810 | transport | biological_process | |
| GO:0006913 | nucleocytoplasmic transport | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0016070 | RNA metabolic process | biological_process | |
| GO:0016071 | mRNA metabolic process | biological_process | |
| GO:0031124 | mRNA 3'-end processing | biological_process | |
| GO:0045727 | positive regulation of translation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0035145 | exon-exon junction complex | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003729 | mRNA binding | molecular_function | |
| GO:0005487 | nucleocytoplasmic transporter activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |