SIL1 nucleotide exchange factor

Symbol

SIL1 (may also be known as: None)

Organism

Human

Description

This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CG10420 Drosophila melanogaster
Sil1 Mus musculus
Sil1 Rattus norvegicus
SIL1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4067 Gene expression of SIL1 decreases with age Molecular skin Human SIL1 —

GO Terms

GO IDGO TermGO Category
GO:0006457 protein folding biological_process
GO:0006886 intracellular protein transport biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0005488 binding molecular_function
GO:0051082 unfolded protein binding molecular_function