LIM homeobox 5

Symbol

LHX5 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lin-11 Caenorhabditis elegans
lhx5 Danio rerio
Lhx5 Mus musculus
Lhx5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2626 Hypermethylation of LHX5 is positively correlated with age Molecular blood Human LHX5 —

GO Terms

GO IDGO TermGO Category
GO:0021527 spinal cord association neuron differentiation biological_process
GO:0021549 cerebellum development biological_process
GO:0021702 cerebellar Purkinje cell differentiation biological_process
GO:0021766 hippocampus development biological_process
GO:0021846 cell proliferation in forebrain biological_process
GO:0021879 forebrain neuron differentiation biological_process
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0005634 nucleus cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function