xylosyltransferase II
Symbol
XYLT2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| oxt | Drosophila melanogaster | |
| Xylt2 | Mus musculus | |
| Xylt2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006024 | glycosaminoglycan biosynthetic process | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0008375 | acetylglucosaminyltransferase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |
| GO:0016757 | transferase activity, transferring glycosyl groups | molecular_function | |
| GO:0030158 | protein xylosyltransferase activity | molecular_function | |