SPARC related modular calcium binding 2
Symbol
SMOC2
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| Smoc2 | Mus musculus | |
| Smoc2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007165 | signal transduction | biological_process | |
| GO:0010811 | positive regulation of cell-substrate adhesion | biological_process | |
| GO:0030198 | extracellular matrix organization | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005578 | proteinaceous extracellular matrix | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0005614 | interstitial matrix | cellular_component | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0008201 | heparin binding | molecular_function | |