chemokine (C-C motif) ligand 21

Symbol

CCL21 (may also be known as: None)

Organism

Human

Description

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, May 2013]

Orthologs

SymbolSpecies
CU693369.1 Danio rerio
Ccl21a Mus musculus
Ccl21 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3384 Gene expression of CCL21 decreases with age Molecular skin Human CCL21 —

GO Terms

GO IDGO TermGO Category
GO:0001768 establishment of T cell polarity biological_process
GO:0001771 immunological synapse formation biological_process
GO:0001954 positive regulation of cell-matrix adhesion biological_process
GO:0002407 dendritic cell chemotaxis biological_process
GO:0002606 positive regulation of dendritic cell antigen processing and presentation biological_process
GO:0006954 inflammatory response biological_process
GO:0006955 immune response biological_process
GO:0007267 cell-cell signaling biological_process
GO:0010560 positive regulation of glycoprotein biosynthetic process biological_process
GO:0030838 positive regulation of actin filament polymerization biological_process
GO:0031274 positive regulation of pseudopodium assembly biological_process
GO:0031295 T cell costimulation biological_process
GO:0031529 ruffle organization biological_process
GO:0032862 activation of Rho GTPase activity biological_process
GO:0033630 positive regulation of cell adhesion mediated by integrin biological_process
GO:0034695 response to prostaglandin E stimulus biological_process
GO:0035759 mesangial cell-matrix adhesion biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity biological_process
GO:0045860 positive regulation of protein kinase activity biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0048260 positive regulation of receptor-mediated endocytosis biological_process
GO:0048469 cell maturation biological_process
GO:0050921 positive regulation of chemotaxis biological_process
GO:0051209 release of sequestered calcium ion into cytosol biological_process
GO:0051491 positive regulation of filopodium assembly biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0090023 positive regulation of neutrophil chemotaxis biological_process
GO:0097026 dendritic cell dendrite assembly biological_process
GO:2000107 negative regulation of leukocyte apoptosis biological_process
GO:2000147 positive regulation of cell motility biological_process
GO:2000529 positive regulation of myeloid dendritic cell chemotaxis biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0008009 chemokine activity molecular_function
GO:0031732 CCR7 chemokine receptor binding molecular_function