receptor-like tyrosine kinase
Symbol
Organism
Description
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Orthologs
Symbol | Species | |
---|---|---|
lin-18 | Caenorhabditis elegans | |
drl | Drosophila melanogaster | |
ryk | Danio rerio | |
Ryk | Mus musculus | |
Ryk | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0006468 | protein phosphorylation | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0007411 | axon guidance | biological_process | |
GO:0016055 | Wnt receptor signaling pathway | biological_process | |
GO:0022038 | corpus callosum development | biological_process | |
GO:0030182 | neuron differentiation | biological_process | |
GO:0031175 | neuron projection development | biological_process | |
GO:0043410 | positive regulation of MAPKKK cascade | biological_process | |
GO:0048705 | skeletal system morphogenesis | biological_process | |
GO:0048843 | negative regulation of axon extension involved in axon guidance | biological_process | |
GO:0050919 | negative chemotaxis | biological_process | |
GO:0071679 | commissural neuron axon guidance | biological_process | |
GO:0005624 | membrane fraction | cellular_component | |
GO:0005634 | nucleus | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0005887 | integral to plasma membrane | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0000166 | nucleotide binding | molecular_function | |
GO:0004713 | protein tyrosine kinase activity | molecular_function | |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | molecular_function | |
GO:0004872 | receptor activity | molecular_function | |
GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
GO:0005109 | frizzled binding | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0005524 | ATP binding | molecular_function | |
GO:0016772 | transferase activity, transferring phosphorus-containing groups | molecular_function | |
GO:0017147 | Wnt-protein binding | molecular_function | |