retinoid X receptor, alpha

Symbol

RXRA (may also be known as: None)

Organism

Human

Description

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Orthologs

SymbolSpecies
rxraa Danio rerio
Rxra Mus musculus
Rxra Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3372 Gene expression of RXRA increases with age Molecular skin Human RXRA —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001889 liver development biological_process
GO:0001890 placenta development biological_process
GO:0006766 vitamin metabolic process biological_process
GO:0006954 inflammatory response biological_process
GO:0007494 midgut development biological_process
GO:0007507 heart development biological_process
GO:0007565 female pregnancy biological_process
GO:0007568 aging biological_process
GO:0007584 response to nutrient biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0010269 response to selenium ion biological_process
GO:0010467 gene expression biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0019048 virus-host interaction biological_process
GO:0031103 axon regeneration biological_process
GO:0032526 response to retinoic acid biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0033280 response to vitamin D biological_process
GO:0035357 peroxisome proliferator activated receptor signaling pathway biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045471 response to ethanol biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048384 retinoic acid receptor signaling pathway biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process
GO:0055012 ventricular cardiac muscle cell differentiation biological_process
GO:0060038 cardiac muscle cell proliferation biological_process
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development biological_process
GO:0060687 regulation of branching involved in prostate gland morphogenesis biological_process
GO:0000790 nuclear chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0030424 axon cellular_component
GO:0003677 DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003707 steroid hormone receptor activity molecular_function
GO:0003708 retinoic acid receptor activity molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0004886 9-cis retinoic acid receptor activity molecular_function
GO:0005496 steroid binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0042809 vitamin D receptor binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0044323 retinoic acid-responsive element binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0070644 vitamin D response element binding molecular_function