3-hydroxybutyrate dehydrogenase, type 1

Symbol

BDH1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CG8888 Drosophila melanogaster
bdh1 Danio rerio
Bdh1 Mus musculus
Bdh1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0007420 brain development biological_process
GO:0007584 response to nutrient biological_process
GO:0008152 metabolic process biological_process
GO:0009636 response to toxin biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0032355 response to estradiol stimulus biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0042493 response to drug biological_process
GO:0042594 response to starvation biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045471 response to ethanol biological_process
GO:0046686 response to cadmium ion biological_process
GO:0046950 cellular ketone body metabolic process biological_process
GO:0046951 ketone body biosynthetic process biological_process
GO:0046952 ketone body catabolic process biological_process
GO:0051412 response to corticosterone stimulus biological_process
GO:0060416 response to growth hormone stimulus biological_process
GO:0060612 adipose tissue development biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003858 3-hydroxybutyrate dehydrogenase activity molecular_function
GO:0005543 phospholipid binding molecular_function
GO:0016491 oxidoreductase activity molecular_function