3-hydroxybutyrate dehydrogenase, type 1
Symbol
BDH1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG8888 | Drosophila melanogaster | |
| bdh1 | Danio rerio | |
| Bdh1 | Mus musculus | |
| Bdh1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001889 | liver development | biological_process | |
| GO:0007420 | brain development | biological_process | |
| GO:0007584 | response to nutrient | biological_process | |
| GO:0008152 | metabolic process | biological_process | |
| GO:0009636 | response to toxin | biological_process | |
| GO:0009725 | response to hormone stimulus | biological_process | |
| GO:0032355 | response to estradiol stimulus | biological_process | |
| GO:0032868 | response to insulin stimulus | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0042594 | response to starvation | biological_process | |
| GO:0044255 | cellular lipid metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0045471 | response to ethanol | biological_process | |
| GO:0046686 | response to cadmium ion | biological_process | |
| GO:0046950 | cellular ketone body metabolic process | biological_process | |
| GO:0046951 | ketone body biosynthetic process | biological_process | |
| GO:0046952 | ketone body catabolic process | biological_process | |
| GO:0051412 | response to corticosterone stimulus | biological_process | |
| GO:0060416 | response to growth hormone stimulus | biological_process | |
| GO:0060612 | adipose tissue development | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005743 | mitochondrial inner membrane | cellular_component | |
| GO:0005759 | mitochondrial matrix | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003858 | 3-hydroxybutyrate dehydrogenase activity | molecular_function | |
| GO:0005543 | phospholipid binding | molecular_function | |
| GO:0016491 | oxidoreductase activity | molecular_function | |