ribosomal protein S6 kinase, 90kDa, polypeptide 2

Symbol

RPS6KA2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
rps6ka2 Danio rerio
Rps6ka2 Mus musculus
Rps6ka2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2829 Gene expression of RPS6KA2 increases with age Molecular adipose tissue Human RPS6KA2 —

GO Terms

GO IDGO TermGO Category
GO:0000089 mitotic metaphase biological_process
GO:0001556 oocyte maturation biological_process
GO:0002035 brain renin-angiotensin system biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0007165 signal transduction biological_process
GO:0007243 intracellular protein kinase cascade biological_process
GO:0007268 synaptic transmission biological_process
GO:0007411 axon guidance biological_process
GO:0007507 heart development biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0010659 cardiac muscle cell apoptosis biological_process
GO:0018105 peptidyl-serine phosphorylation biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0045087 innate immune response biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0060047 heart contraction biological_process
GO:0070613 regulation of protein processing biological_process
GO:0071322 cellular response to carbohydrate stimulus biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005819 spindle cellular_component
GO:0005829 cytosol cellular_component
GO:0005840 ribosome cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0000287 magnesium ion binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004711 ribosomal protein S6 kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function