ROS proto-oncogene 1 , receptor tyrosine kinase
Symbol
ROS1
(may also be known as: None)
Organism
Human
Description
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| rol-3 | Caenorhabditis elegans | |
| sev | Drosophila melanogaster | |
| ros1 | Danio rerio | |
| Ros1 | Mus musculus | |
| Ros1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002066 | columnar/cuboidal epithelial cell development | biological_process | |
| GO:0006468 | protein phosphorylation | biological_process | |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_process | |
| GO:0007283 | spermatogenesis | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0010629 | negative regulation of gene expression | biological_process | |
| GO:0010966 | regulation of phosphate transport | biological_process | |
| GO:0016049 | cell growth | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0032006 | regulation of TOR signaling cascade | biological_process | |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | biological_process | |
| GO:0005624 | membrane fraction | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0019903 | protein phosphatase binding | molecular_function | |