RAR-related orphan receptor A
Symbol
RORA
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| roraa | Danio rerio | |
| Rora | Mus musculus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2828 | Gene expression of RORA decreases with age | Molecular | adipose tissue | Human | RORA | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006809 | nitric oxide biosynthetic process | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0021702 | cerebellar Purkinje cell differentiation | biological_process | |
| GO:0030522 | intracellular receptor mediated signaling pathway | biological_process | |
| GO:0043030 | regulation of macrophage activation | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0046068 | cGMP metabolic process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003707 | steroid hormone receptor activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |