tumor necrosis factor receptor superfamily, member 17
Symbol
TNFRSF17
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Tnfrsf17 | Mus musculus | |
| Tnfrsf17 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2408 | tumor necrosis factor receptor superfamily; member 17 decreases with age | Molecular | dermis | Human | TNFRSF17 | 17.6% Decrease DNA Methylation | |
| DAA2457 | tumor necrosis factor receptor superfamily; member 17 increases with age | Molecular | mesenchymal stem cell | Human | TNFRSF17 | 18.8% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007165 | signal transduction | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0012505 | endomembrane system | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005031 | tumor necrosis factor-activated receptor activity | molecular_function | |