regulator of G-protein signaling 12
Symbol
RGS12
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| loco | Drosophila melanogaster | |
| rgs12b | Danio rerio | |
| Rgs12 | Mus musculus | |
| Rgs12 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007165 | signal transduction | biological_process | |
| GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | biological_process | |
| GO:0038032 | termination of G-protein coupled receptor signaling pathway | biological_process | |
| GO:0043547 | positive regulation of GTPase activity | biological_process | |
| GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | biological_process | |
| GO:0000794 | condensed nuclear chromosome | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005057 | receptor signaling protein activity | molecular_function | |
| GO:0005096 | GTPase activator activity | molecular_function | |
| GO:0030695 | GTPase regulator activity | molecular_function | |