replication factor C (activator 1) 4, 37kDa

Symbol

RFC4 (may also be known as: None)

Organism

Human

Description

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
rfc-4 Caenorhabditis elegans
CG8142 Drosophila melanogaster
rfc4 Danio rerio
Rfc4 Mus musculus
Rfc4 Rattus norvegicus
RFC2 Saccharomyces cerevisiae
rfc2 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3362 Gene expression of RFC4 increases with age Molecular skin Human RFC4 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0000722 telomere maintenance via recombination biological_process
GO:0000723 telomere maintenance biological_process
GO:0006260 DNA replication biological_process
GO:0006271 DNA strand elongation involved in DNA replication biological_process
GO:0006281 DNA repair biological_process
GO:0006283 transcription-coupled nucleotide-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006297 nucleotide-excision repair, DNA gap filling biological_process
GO:0032201 telomere maintenance via semi-conservative replication biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005663 DNA replication factor C complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003689 DNA clamp loader activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0017111 nucleoside-triphosphatase activity molecular_function