junctional adhesion molecule 2
Symbol
JAM2
(may also be known as: None)
Organism
Human
Description
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| Jam2 | Mus musculus | |
| Jam2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0016337 | cell-cell adhesion | biological_process | |
| GO:0050900 | leukocyte migration | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0005923 | tight junction | cellular_component | |
| GO:0030054 | cell junction | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0046982 | protein heterodimerization activity | molecular_function | |