prostaglandin D2 synthase 21kDa (brain)

Symbol

PTGDS (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
zgc:153704 Danio rerio
Ptgds Mus musculus
Ptgds Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2759 Hypomethylation of PTGDS is positively correlated with age Molecular blood Human PTGDS —

GO Terms

GO IDGO TermGO Category
GO:0001516 prostaglandin biosynthetic process biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0006810 transport biological_process
GO:0045187 regulation of circadian sleep/wake cycle, sleep biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005791 rough endoplasmic reticulum cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0016020 membrane cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004667 prostaglandin-D synthase activity molecular_function
GO:0005215 transporter activity molecular_function
GO:0005488 binding molecular_function
GO:0005501 retinoid binding molecular_function
GO:0005504 fatty acid binding molecular_function
GO:0016853 isomerase activity molecular_function