proteasome (prosome, macropain) subunit, beta type, 5

Symbol

PSMB5 (may also be known as: None)

Organism

Human

Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Orthologs

SymbolSpecies
psmb5 Danio rerio
Psmb5 Mus musculus
Psmb5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3347 Gene expression of PSMB5 decreases with age Molecular skin Human PSMB5 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0000216 M/G1 transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0006521 regulation of cellular amino acid metabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest biological_process
GO:0006979 response to oxidative stress biological_process
GO:0010467 gene expression biological_process
GO:0016032 viral reproduction biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051603 proteolysis involved in cellular protein catabolic process biological_process
GO:0000502 proteasome complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005839 proteasome core complex cellular_component
GO:0004298 threonine-type endopeptidase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008233 peptidase activity molecular_function