SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Symbol
SMARCAD1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| M03C11.8 | Caenorhabditis elegans | |
| Etl1 | Drosophila melanogaster | |
| smarcad1a | Danio rerio | |
| Smarcad1 | Mus musculus | |
| Smarcad1 | Rattus norvegicus | |
| FUN30 | Saccharomyces cerevisiae | |
| fft1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000018 | regulation of DNA recombination | biological_process | |
| GO:0009117 | nucleotide metabolic process | biological_process | |
| GO:0016568 | chromatin modification | biological_process | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
| GO:0051260 | protein homooligomerization | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0016363 | nuclear matrix | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0004386 | helicase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |