pannexin 2

Symbol

PANX2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Orthologs

Symbol	Species
panx2	Danio rerio
Panx2	Mus musculus
Panx2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data
DAA3990	Gene expression of PANX2 increases with age	Molecular	skin	Human	PANX2	—
DAA2353	Pannexin 2 decreases with age	Molecular	temporal lobe	Human	PANX2	16.5% Decrease Gene Expression Level
DAA2352	Pannexin 2 decreases with age	Molecular	hippocampus	Human	PANX2	19.1% Decrease Gene Expression Level
DAA2351	Pannexin 2 decreases with age	Molecular	frontal lobe	Human	PANX2	8.1% Decrease Gene Expression Level

First
Last

GO Terms

GO ID	GO Term	GO Category
GO:0006811	ion transport	biological_process
GO:0007268	synaptic transmission	biological_process
GO:0034214	protein hexamerization	biological_process
GO:0005886	plasma membrane	cellular_component
GO:0005921	gap junction	cellular_component
GO:0016021	integral to membrane	cellular_component
GO:0030054	cell junction	cellular_component
GO:0005216	ion channel activity	molecular_function
GO:0046982	protein heterodimerization activity	molecular_function
GO:0055077	gap junction hemi-channel activity	molecular_function