polymerase (DNA-directed), epsilon 4, accessory subunit
Symbol
POLE4
(may also be known as: None)
Organism
Human
Description
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Orthologs
| Symbol | Species | |
|---|---|---|
| Mes4 | Drosophila melanogaster | |
| zgc:110337 | Danio rerio | |
| Pole4 | Mus musculus | |
| Pole4 | Rattus norvegicus | |
| SPCC16C4.22 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0043966 | histone H3 acetylation | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | cellular_component | |
| GO:0003887 | DNA-directed DNA polymerase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |
| GO:0016779 | nucleotidyltransferase activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |