sulfatase 2

Symbol

SULF2 (may also be known as: None)

Organism

Human

Description

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Orthologs

SymbolSpecies
sul-1 Caenorhabditis elegans
sulf2l Danio rerio
Sulf2 Mus musculus
Sulf2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3975 Gene expression of SULF2 decreases with age Molecular skin Human SULF2 —

GO Terms

GO IDGO TermGO Category
GO:0001822 kidney development biological_process
GO:0002063 chondrocyte development biological_process
GO:0003094 glomerular filtration biological_process
GO:0010575 positive regulation vascular endothelial growth factor production biological_process
GO:0014846 esophagus smooth muscle contraction biological_process
GO:0030177 positive regulation of Wnt receptor signaling pathway biological_process
GO:0030201 heparan sulfate proteoglycan metabolic process biological_process
GO:0032836 glomerular basement membrane development biological_process
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway biological_process
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway biological_process
GO:0048706 embryonic skeletal system development biological_process
GO:0051216 cartilage development biological_process
GO:0060348 bone development biological_process
GO:0060384 innervation biological_process
GO:0005615 extracellular space cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005795 Golgi stack cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0003824 catalytic activity molecular_function
GO:0004065 arylsulfatase activity molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0008449 N-acetylglucosamine-6-sulfatase activity molecular_function
GO:0008484 sulfuric ester hydrolase activity molecular_function
GO:0016787 hydrolase activity molecular_function