mitogen-activated protein kinase 3

Symbol

MAPK3 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
mpk-1 Caenorhabditis elegans
rl Drosophila melanogaster
Mapk3 Mus musculus
Mapk3 Rattus norvegicus
KSS1 Saccharomyces cerevisiae
spk1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3341 Gene expression of MAPK3 decreases with age Molecular skin Human MAPK3 —

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0000186 activation of MAPKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0000189 MAPK import into nucleus biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006360 transcription from RNA polymerase I promoter biological_process
GO:0006361 transcription initiation from RNA polymerase I promoter biological_process
GO:0006461 protein complex assembly biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006915 apoptotic process biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0007049 cell cycle biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007265 Ras protein signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0007596 blood coagulation biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0009636 response to toxin biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010467 gene expression biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019233 sensory perception of pain biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0030168 platelet activation biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032872 regulation of stress-activated MAPK cascade biological_process
GO:0033129 positive regulation of histone phosphorylation biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035066 positive regulation of histone acetylation biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0043330 response to exogenous dsRNA biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045087 innate immune response biological_process
GO:0045727 positive regulation of translation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051216 cartilage development biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0051493 regulation of cytoskeleton organization biological_process
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway biological_process
GO:0070498 interleukin-1-mediated signaling pathway biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0072584 caveolin-mediated endocytosis biological_process
GO:0090170 regulation of Golgi inheritance biological_process
GO:2000641 regulation of early endosome to late endosome transport biological_process
GO:2000657 negative regulation of apolipoprotein binding biological_process
GO:0005625 soluble fraction cellular_component
GO:0005626 insoluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005769 early endosome cellular_component
GO:0005770 late endosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005901 caveola cellular_component
GO:0005925 focal adhesion cellular_component
GO:0031143 pseudopodium cellular_component
GO:0043234 protein complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001784 phosphotyrosine binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004707 MAP kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0019902 phosphatase binding molecular_function