protein kinase N1


PKN1 (may also be known as: None)




The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]


zgc:162290 Danio rerio
Pkn1 Mus musculus
Pkn1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2447 protein kinase N1 isoform 2 increases with age Molecular mesenchymal stem cell Human PKN1 27.7% Increase DNA Methylation
DAA2398 protein kinase N1 isoform 2 increases with age Molecular dermis Human PKN1 17.6% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007165 signal transduction biological_process
GO:0007257 activation of JUN kinase activity biological_process
GO:0010631 epithelial cell migration biological_process
GO:0016568 chromatin modification biological_process
GO:0035407 histone H3-T11 phosphorylation biological_process
GO:2000145 regulation of cell motility biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0030496 midbody cellular_component
GO:0032154 cleavage furrow cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004697 protein kinase C activity molecular_function
GO:0005080 protein kinase C binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0017049 GTP-Rho binding molecular_function
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity molecular_function
GO:0035402 histone kinase activity (H3-T11 specific) molecular_function
GO:0042393 histone binding molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0048365 Rac GTPase binding molecular_function
GO:0050681 androgen receptor binding molecular_function