NOP10 ribonucleoprotein
Symbol
NOP10
(may also be known as: None)
Organism
Human
Description
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| C25A1.6 | Caenorhabditis elegans | |
| CG7637 | Drosophila melanogaster | |
| nop10 | Danio rerio | |
| Nop10 | Mus musculus | |
| LOC100360065 | Rattus norvegicus | |
| NOP10 | Saccharomyces cerevisiae | |
| nop10 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001522 | pseudouridine synthesis | biological_process | |
| GO:0006364 | rRNA processing | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005732 | small nucleolar ribonucleoprotein complex | cellular_component | |
| GO:0015030 | Cajal body | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |