protein phosphatase 2, regulatory subunit A, beta

Symbol

PPP2R1B (may also be known as: None)

Organism

Human

Description

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Orthologs

SymbolSpecies
paa-1 Caenorhabditis elegans
Pp2A-29B Drosophila melanogaster
ppp2r1b Danio rerio
Ppp2r1b Mus musculus
Ppp2r1b Rattus norvegicus
paa1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006886 intracellular protein transport biological_process
GO:0016192 vesicle-mediated transport biological_process
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0030117 membrane coat cellular_component
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function