slingshot protein phosphatase 3
Symbol
SSH3
(may also be known as: None)
Organism
Human
Description
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CR847496.2 | Danio rerio | |
| Ssh3 | Mus musculus | |
| Ssh3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | biological_process | |
| GO:0008064 | regulation of actin polymerization or depolymerization | biological_process | |
| GO:0010591 | regulation of lamellipodium assembly | biological_process | |
| GO:0050770 | regulation of axonogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0004725 | protein tyrosine phosphatase activity | molecular_function | |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0016791 | phosphatase activity | molecular_function | |