transient receptor potential cation channel, subfamily M, member 4

Symbol

TRPM4 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Orthologs

SymbolSpecies
uncharacterized_E7F9 Danio rerio
Trpm4 Mus musculus
Trpm4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3904 Gene expression of TRPM4 increases with age Molecular skin Human TRPM4 —

GO Terms

GO IDGO TermGO Category
GO:0002407 dendritic cell chemotaxis biological_process
GO:0002724 regulation of T cell cytokine production biological_process
GO:0006811 ion transport biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0016925 protein sumoylation biological_process
GO:0055085 transmembrane transport biological_process
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004872 receptor activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005227 calcium activated cation channel activity molecular_function
GO:0005262 calcium channel activity molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005524 ATP binding molecular_function