FEV (ETS oncogene family)
Symbol
FEV
(may also be known as: None)
Organism
Human
Description
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| fev | Danio rerio | |
| Fev | Mus musculus | |
| Fev | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007399 | nervous system development | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003690 | double-stranded DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003714 | transcription corepressor activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |