carnitine O-octanoyltransferase

Symbol

CROT (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

Orthologs

SymbolSpecies
CELE_F41E7.6 Caenorhabditis elegans
CG12428 Drosophila melanogaster
crot Danio rerio
Crot Mus musculus
Crot Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3899 Gene expression of CROT increases with age Molecular skin Human CROT —

GO Terms

GO IDGO TermGO Category
GO:0006631 fatty acid metabolic process biological_process
GO:0006635 fatty acid beta-oxidation biological_process
GO:0006810 transport biological_process
GO:0008152 metabolic process biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0015908 fatty acid transport biological_process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase biological_process
GO:0042493 response to drug biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005625 soluble fraction cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005777 peroxisome cellular_component
GO:0005782 peroxisomal matrix cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0008458 carnitine O-octanoyltransferase activity molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function